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IMPORTANT NEWS! GHK-Cu Study on Acute Lung Injury

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 2016 Aug 10. doi: 10.18632/oncotarget.11168. [Epub ahead of print]

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.

Abstract

The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound healing and tissue remodeling. Although GHK-Cu exhibits anti-aging and tissue renewing properties, its roles in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still unknown.

Therefore, we examined the effects of GHK-Cu in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in vitro and ALI in mice in vivo. GHK-Cu treatment reduced reactive oxygen species (ROS) production, increased superoxide dismutase (SOD) activity while decreased TNF-α and IL-6 production through the suppression of NF-κB p65 and p38 MAPK signaling in vitro and in vivo model of ALI.

Moreover, GHK-Cu attenuated LPS-induced lung histological alterations, suppressed the infiltration of inflammatory cells into the lung parenchyma in LPS-induced ALI in mice.

Taken together, these findings demonstrate that GHK-Cu possesses a protective effect in LPS-induced ALI by inhibiting excessive inflammatory responses; accordingly it may represent a novel therapeutic approach for ALI/ARDS.

Dr. Loren Pickart who has a BA in Chemistry and Mathematics from the University of Minnesota and a PhD in Biochemistry from the University of California, San Francisco is dedicated to the research and further discussion of biochemistry, science, and health in all its applications.

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