Dr. Pickart had me post this for your reading enjoyment. In 1984, I observed that GHK-Cu possesses a mild antioxidant activity similar to the enzyme superoxide dismutase, which manifests itself as a calming of red and irritated skin. Steve Aust’s lab at Utah State University discovered that GHK-Cu blocks the damage-induced release of oxidizing iron molecules from ferritin. Further discoveries followed. Vinci et al. at the University of Catalina in Italy reported that GHK-Cu blocks tissue...

GHK- Anti-Pain (Analgesic) and Anti-Anxiety (Anxiolytic) Actions 1. Opiate peptides help with wound healing and pain control. This appears to be mediated through the opioid mu1 recpetors. 2. GHK possesses both wound healing and anti-pain activities. Based on Broad Institute data, GHK increases expression of the opioid mu1 gene OPRM1 by 13.9 fold. It also increases gene expression of the cannabinoid pain-reducing gene CNR1 by 2.7 fold (average of +3.1 and +2.3). 3. This anti-pain and wound...

GHK & Wound Healing: Built-In Natural Regulator of Dermal Repair The wound healing process in the skin goes through the following phases: hemostasis (blood clotting), inflammation, granulation, and scar remodeling. Every stage requires well-coordinated cell interaction and therefore is precisely orchestrated by a plethora of biological active molecules coming from different sources. For example, immediately after injury degranulating platelets release growth factors (such as TGF-beta)...

Resetting Skin Genome Back to Health Naturally with GHK Textbook of Aging Skin (Reference Book Abstract) The copper-binding tripeptide GHK (glycyl- l -histidyl- l -lysine) is a naturally occurring plasma peptide widely used in skin care products. It is especially popular in antiaging cosmetic formulations due to its various and well-established positive biological effects on aging skin. It has been established that GHK-Cu improves wound healing and tissue regeneration and stimulates collagen...

An Ounce of Prevention It may be as long as 10-20 years, before someone with diabetes may develop visible complications surface in the form of skin problems. Of course the best time to start fighting for your skin’s beauty and radiance is when it is still healthy. However, it is never too late to start caring for your skin, even when you start develop dryness and increased sensitivity. Diabetes may make your skin age faster due to A dvanced G lycation E nd products, which accumulate in the...

Visual Presentation of Cancer Metastasis Genetic Data and GHK VISIT: www.skinbiology.com/wound-healing-society-2011.htm Dr. Loren Pickart presented the following visual at the Society for the Advancement of Wound Care and the Wound Healing Society in Dallas, Texas. The presentation focused on data confirming that GHK may inhibit cancer genes, suggesting a connection between metastatic cancer cells and similar systems utilized in the early stage of wound healing.

DMSO & GHK: A Success Story Background & Observations : GHK-Cu improved the skin transplants with the best results being obtained by using GHK-Cu dissolved in a small amount of DMSO (dimethylsulfoxide). Normally in skin grafts, most of the grafted skin dies off, and new skin grows outward from the surviving core of the skin graft. However, the addition of DMSO often so improved the graft "take" that the final graft "take" area exceeded the actual size of the skin graft. Periphery of...

 StudyResultReference US Patents describing methods using GHK-Cu stimulating wound healing of wound and methods for enhancing wound healing through an animalUS Patent 4,665,054   New glycyl-L-histidyl-L-lysine copper derivatives of...

Hi I wonder is it ok to add a touch of DMSO to a jar of skin cream that is organic and filled with nourishment so that it would go deeper into the skin for better results ? I have some DMSO 99% unopened still .

DMSO is added to many GHK products. But you only need a little, such as 1 to 2% if you add it yourself.

Wow that is awesome !

Hi Dr . Pickart , why do you say Crepey Skin Escape is not meant to be used around the eye area ? I read this statement but you don't say why . Is it because it contains DMSO ?

I don't think it will cause any problems. We just are somewhat over-cautious on newer products. Crepey Skin Escape is receiving great reviews. As for DMSO, I still have not found any real evidence for toxicities. Mechanics have used it for many decades to remove grease from auto parts.

Thank you Dr . Pickart , I intend to use it on my face as well as my neck and decollete when my order arrives .

I understand the hint!

It is a very interesting review. We have developed a computational platform ( www.persistent.com/eskin ) for skin research, wherein skin associated pathways like Keratinocyte Differentiation, Wound Healing, Cornification are built. The role of TGF-beta in wound healing is well studied and accommodated in our pathways. It will be valuable to incorporate this information in our pathway models.

Dear INDHUPRIYA , Feel free to incorporate any of the GHK data from our research site at: ReverseAgingwithGHK.com - You'll find a wealth of very valuable information that might be of use to you in your pathway models. Data from any of any of Dr. Pickart's Published Articles and Presentations can also be found at: www.skinbiology.com/published-...s-presentations.html Please contact Dr. Pickart directly at: lorenpickart@skinbiology.com with any further questions you may have. Best Wishes, SKIN...