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Tagged With "Biological Mechanism of Action"

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Re: GHK WITH COPD

Mike Smalling ·
Dr. Pickart, My name is Mike Smalling, and I’m currently a grad student at Louisiana Tech University studying in molecular science. I have read many of your papers, and became very interested in the tripeptide GHK through them. I have also read Dr. Campbell’s work on COPD, and Dr. Lane’s work with SPARC as well as others. I intended to do a master’s thesis on research of the tripeptide, but after I had gotten through the initial research, my advisors here realized I was in an area they were...
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Re: Reversal of Emphysema-Related Lung Destruction?

Dr. Loren Pickart ·
There are new reports of lung protection by GHK. 1. . 2016 Sep 6; 7(36): 58405–58417. Published online 2016 Aug 10. doi: 10.18632/oncotarget.11168 PMCID: PMC5295439 The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice Jeong-Ran Park,1,2 Hanbyeol Lee,1 Seok-In Kim,3 and Se-Ran Yang1Oncotarget The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound healing and tissue remodeling. Although GHK-Cu exhibits...
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Wound Healing & Skin Repair Using Copper Peptides

skinbiologywebmaster ·
 StudyResultReference US Patents describing methods using GHK-Cu stimulating wound healing of wound and methods for enhancing wound healing through an animalUS Patent 4,665,054   New glycyl-L-histidyl-L-lysine copper derivatives of...
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GHK Anti-Pain (Analgesic)

skinbiologywebmaster ·
GHK- Anti-Pain (Analgesic) and Anti-Anxiety (Anxiolytic) Actions 1. Opiate peptides help with wound healing and pain control. This appears to be mediated through the opioid mu1 recpetors. 2. GHK possesses both wound healing and anti-pain activities. Based on Broad Institute data, GHK increases expression of the opioid mu1 gene OPRM1 by 13.9 fold. It also increases gene expression of the cannabinoid pain-reducing gene CNR1 by 2.7 fold (average of +3.1 and +2.3). 3. This anti-pain and wound...
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GHK and Anti-Anxiety

skinbiologywebmaster ·
Anti-Anxiety (Anxiolytic) Use of peptide gly-his-lys for anxiolytic effect. RU patent 2480232.   SUBSTANCE: invention refers to medicine, namely physiology, pathophysiology and pharmacology, and may be used for an anxiolytic (antianxiety) effect....
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GHK and Bone Healing in Humans!

Skin Biology ·
The people at the University of Kursk in Russia have found an improved method in the use of GHK. They used Gly-His-Lys (0.5 μg/kg), dalargin (1.2 μg/kg) (an opioid-like synthetic drug) and and biological peptide thymogen (0.5 μg/kg) (dipeptide,L-glutamyl-L-tryptophan) to heal bones. The total peptide dosage is about 2 micrograms per KG or about 140 micrograms in a human. It has been established, that in case of experimental rat bone fractures the intraperitoneally injections of peptides in...
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GHK Anti-Pain and Anti-Anxiety Actions: What Does It Mean?

Skin Biology ·
GHK- Anti-Pain (Analgesic) and Anti-Anxiety (Anxiolytic) Actions: Study Reveals Interesting Effects   Application of peptide gly-his-lys for analgesic [anti-pain] effect in pain caused by thermal irritation. RU patent 2421235.   EFFECT:  Invention allows applying known peptide Gly-His-Lys with manifested analgesic effect for a new purpose.   The invention relates to medicine, namely to the physiology and pathophysiology, and can be used for an analgesic effect in the pain...
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Rosacea: Endoplasmic reticulum stress(Pandora) and possible effects by GHK/Copper

Ilia ·
Good day! I found good 2016 article from Germany about rosacea cell mechanisms. Dr. Pickart or anybody, do You have any information of correlation of GHK/Copper with endoplasmatic reticulum(as Pandora of rosacea)? any positive regulative effects on ER? I add this article full text.
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Anti-Aggression, Anti-Anxiety, Anti-Pain

Dr. Loren Pickart ·
GHK effects: Anti-aggression, Anti-anxiety, Anti-pain Anti-aggression actions Comment. The anti-aggression actions of GHK, if scaled up for a human, would occur at a dosage of about 0.3 mgs. The GHK is produced in Russia at the State University of Saint Petersburg, Putin's school. So the Russians can spray opposing armies with GHK and turn them into 1970s style California flower children. Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats Bulletin of...
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RUSSIAN Articles: Biological Mechanism of Action of GHK-Cu TriPeptide

Skin Biology ·
The primary cause of human aging and its attendant diseases are changes in the activity of the human genome. During aging there is an increase in the activity of inflammatory, cancer promoting, and tissue destructive genes plus a decrease in the activity of regenerative and reparative genes. Regenerative copper peptides appear to help maintain wellness and youth. The human peptide GHK induces a plethora of health associated actions such as tissue repair, anti-inflammatory actions,...
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(Russian Articles) - Is GHK the Secret to Unlock Human Aging?

Skin Biology ·
The primary cause of human aging and its attendant diseases are changes in the activity of the human genome. During aging there is an increase in the activity of inflammatory, cancer promoting, and tissue destructive genes plus a decrease in the activity of regenerative and reparative genes. Regenerative copper peptides appear to help maintain wellness and youth. The human peptide GHK induces a plethora of health associated actions such as tissue repair, anti-inflammatory actions,...
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Pure Palmitoyl Pentapeptide-4 /Matrixyl Acetate powder CAS 214047-00-4

Bella-Youngshe ·
What is Palmitoyl Pentapeptide-4 /Matrixyl Acetate? Product Name Pure Palmitoyl Pentapeptide-4 /Matrixyl Acetate powder CAS 214047-00-4 Appearance white powder CAS 214047-00-4 MF C39H75N7O10 MW N/A Purity 99% Application Cosmetic Products Storage Keep in cool & dry place,stay away from strong light and heat picture Palmitoyl pentapeptide-4 (Pal-Lys-Thr-Thr-Lys-Ser = Pal-KTTKS) contains 5 amino acids linked to a 16-carbon aliphatic chain for improving the penetration of the molecule through...
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Whitening Nonapeptide-1/Melitane

Bella-Youngshe ·
Product Name High quality Whitening and anti-freckle Cas 158563-45-2 Nonapeptide-1/Melitane Appearance white powder Assay 99%min Test HPLC Certificate ISO 9001 CAS 158563-45-2 MF C61H87N15O9S Storage Temperature Keep in a cool, dry, dark location in a tightly sealed container or cylinder. What is Nonapeptide-1? Nonapeptide-1, also called Melanostatine-5, is a propriety peptide that was originally developed for its antimicrobial activities. Animal research has revealed, however, that...
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Acetyl Decapeptide-3 reduces and prevent lines and wrinkles

youngshe2015 ·
Acetyl Decapeptide-3 1.Basic information: INCI name: Acetyl Decapeptide-3 Reference: Rejuline MW: 1491 Purity: 95% Grade: cosmetic 2.USE: 1- Acetyl Decapeptide-3 reduces and prevent lines and wrinkles by actively generating new skin cells. 2- Involve in normal skin growth, healing and wound repair. 3- Acetyl Decapeptide-3 Strengthens skin elasticity by inducing the synthesis of collagen and elastin. 4- More stable and prolong action than native proteins.
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