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Tagged With "Recombinant human epidermal growth facto"

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Re: dosing for injections for antiaging

Dr. Loren Pickart ·
There are reports of human injecting GHK-Cu bought from other companies. If someone does this watch the blood pressure which may decrease with a very high dose. I do not recommend injection but if you do this, the keep it to a total to 2 mgs to 20 mgs of GHK-Cu. A possible lethal dose, based on studies in mice, would be about 23,000 mgs injected IV at one time.
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Re: dosing for injections for antiaging

Dr. Loren Pickart ·
From Reddit OK so GHK-Cu is weird. Yesterday I injected 2mg subQ, can't really say if I noticed much, but this morning I injected 4mg subQ and like all my inflammation disappeared. This 4mg was stronger than the highest ibuprofen dose I've ever taken regarding inflammation reduction. (like 1.2 grams ibuprofen). About an hour later I worked out and I've had the strongest pump/soreness I've ever had regarding lifting. Also I'm in a ridiculously good mood and don't feel sluggish mentally...
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Re: dosing for injections for antiaging

Dr. Loren Pickart ·
Hi Dr. Pickart, I've been using GHK-Cu for 4 weeks at 5mg daily. I've had great effects including skin, cognitive function and hair growth, it's pretty incredible! I have a quick question that I'm hoping you can answer. You recommend the purchase of GHK-Cu through Ceretropic. I'm curious what dose people use for anti aging effects. I'm concerned of copper toxicity and taking to much of GHK-Cu. I've spoken with you on the phone and had a great conversation with you! You're done amazing work...
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Re: dosing for injections for antiaging

PrinLeslieh ·
Re: dosing for injections for antiaging
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Re: dosing for injections for antiaging

Dr. Loren Pickart ·
I don't know of any side effects at the dosages typically used which are 1 to 7 mgs daily. In one kilogram amounts, GHK-Cu costs about $10 a gram or $0.10 per milligram. But we have been under FDA pressure for years about the copper peptides and can say little. We cannot say what all the other sellers of copper peptides say about the actions of copper peptides. I have been told many times by FDA people that we have too much science. SuperSmart sells a sublingual form of 5 mgs GHK-Cu but,...
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Re: dosing for injections for antiaging

Lois R ·
I am needing reconstitution rates. I have purchased a vial of Peptide Science GHK-cu 200 mg. How much bacteriostatic water do I use? I want to be able to give daily doses of 1 mg. Thank you.
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Re: dosing for injections for antiaging

Adam ·
Hello Dr. Pickart, I’ve been following your work for years with much interest You mention; ”The only issue is to keep copper and zinc in a rough balance of about 5 parts zinc to 1 part copper.” In maintaining proper zinc/copper balance are oral zinc supplements suitable for raising zinc levels? Thank you, Adam
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Re: Copper Misconceptions

Jessica ·
Dear Beth, Many of our clients have emailed us with concerns about the safety of copper. Excessive copper has been blamed for many diseases – Alzheimer's, heart disease, cancer, etc. The problem is that most of this comes from data on blood plasma copper and diseases. But usually, high blood plasma copper is associated with low tissue copper. Most plasma copper (60%) is locked in proteins such as in ceruloplasmin - an acute phase reactant that rises with stress and disease, and other...
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Re: Copper Peptides Protect against UV Radiation

Skin Biology ·
Dear SEIHAA : Thanks for posting your questions! We are sure Dr. Pickart will post his thoughts on how this could be used in practical application. But actually you'll find some excellent information at: GHK and Sun Science ( suntanscience.com ) On Dr. Pickart's page outlining his Patent: Compositions & Methods for Suntanning and Protection , just look at the Examples I-IX . That is where Dr. Pickart mentions how he think GHK can be used to accomplish some great effects for the skin.
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Re: GHK WITH COPD

Dr. Loren Pickart ·
This information is for the use of medical researchers and persons interested in health sciences. It must be emphasized that GHK and other copper binding peptides have not been tested on human emphysema and COPD and are not approved for such uses. One way that may help with COPD is to take 6 mg/day of copper glycinate after a meal. Look at the new revision of http://www.skinbiology.com/cop...sema-copd-genes.html . for the reasons behind this idea. It may not stop COPD but it may help to...
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Re: Reversal of Emphysema-Related Lung Destruction?

Dr. Loren Pickart ·
There are new reports of lung protection by GHK. 1. . 2016 Sep 6; 7(36): 58405–58417. Published online 2016 Aug 10. doi: 10.18632/oncotarget.11168 PMCID: PMC5295439 The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice Jeong-Ran Park,1,2 Hanbyeol Lee,1 Seok-In Kim,3 and Se-Ran Yang1Oncotarget The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound healing and tissue remodeling. Although GHK-Cu exhibits...
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Re: dosing for injections for antiaging

Dr. Loren Pickart ·
I would not recommend injecting GHK-Cu. We just have little information on human injections. GHK-Cu passes the stratum corneum rather easily, so just using the product on your skin, should put some GHK-Cu into your body. And GHK-Cu works at 1 nanomolar on cells. The Russian anti-anxiety studies in rats found GHK strongly affects the rats within 12 minutes at a dosage that would correspond to 35 micrograms in humans.
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Re: GHK and Bone Healing in Humans!

henryy123 ·
hi During human age there is an boost in the activity of seditious, cancer promoting, and bandanna critical genes plus a decrease in the activity of regenerative and reparative genes. The human being blood tripeptide GHK possesses many optimistic effects but declines with age. It improves injury healing and tissue renewal (skin, hair follicles, stomach and intestinal linings, and boney tissue) MAGNETIC SCIENCE FUN
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Re: Effect on GHK/Cooper Peptides on PGD2 / PGE2

Jessica ·
Dear Seuxin, Our available data of human genes affected by GHK does not include these prostaglandin genes, unfortunately. However, GHK-Copper does stimulate hair growth in animals and humans. You may find more information at www.folligen.com or www.skinbiology.com . In fact, you may find this particular page quite interesting: http://skinbiology.com/copper-...-of-hair-growth.html . If you scroll down a bit you will find a photo of a mouse with impressive hair growth after being treated with...
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Re: Dosing

Skin Biology ·
Dr. Pickart says: "My earlier estimates of the amount of GHK-Cu needed for human effects were far too high. Since we are in the USA, we only have good reports on GHK-Cu working well at 1 to 7 mgs per day by injection. The SuperSmart GHK-Cu has Linguinal 5 mg GHK-Cu and we have a number of good reports on that product. We don't have much information on the GHK-Cu nasal spray which is sold in Europe and the Middle East."
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Re: GHK & DNA & You

Dr. Loren Pickart ·
US Department of Agriculture studies found the best biochemical anti-oxidants results in humans were with 5 to 6 mgs of supplemental copper daily. More copper will help to some extent. The copper transport molecules are only about 50% loaded with copper in humans and more copper will increase their activity. The Recommended Daily Intake (RDA) of copper is 0.7 mgs daily but this is far too low. A human study found the a group of 24 men on a diet of 1.03 mgs total nutritional copper daily...
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Cancer Suppression with Vitamin C and Copper:Gly-Gly-His

Jessica ·
This information is for the use of medical researchers and persons interested in health sciences. It must be emphasized that GHK and other copper binding peptides have not been tested on human cancers and are not approved for such uses. In 1983...
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GHK Suppression of Cancer Metastasis Genes

Jessica ·
This information is for the use of medical researchers and persons interested in health sciences. It must be emphasized that GHK and other copper binding peptides have not been tested on human cancers and are not approved for such uses. In 2010,...
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Wound Healing & Skin Repair Using Copper Peptides

skinbiologywebmaster ·
 StudyResultReference US Patents describing methods using GHK-Cu stimulating wound healing of wound and methods for enhancing wound healing through an animalUS Patent 4,665,054   New glycyl-L-histidyl-L-lysine copper derivatives of...
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Copper Deficiency

skinbiologywebmaster ·
The majority of data about the symptoms of severe copper deficiency came from animal studies, studies in malnourished children or a rare genetic abnormality - Menkel syndrome. Recently, scientists began to pay attention to signs and consequences of marginal copper deficiency as well. The main sign of severe copper deficiency in animals and humans is anemia that is unresponsive to iron therapy and is accompanied by severe abnormalities in bone marrow. Other symptoms include low white cell...
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Changes in Skin and Hair with Menopause and Aging

skinbiologywebmaster ·
During normal aging, the skin becomes thinner, looser and less elastic and hair growth lessens and the hair shafts become thinner. In men, this is a fairly gradual effect which accelerates after age 45. In women however, the abrupt hormonal changes at...
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GHK & DNA & You

skinbiologywebmaster ·
Dr. Pickart asked me to post this to the forums. Please read and enjoy. Got questions about this musing? Ask and Dr. Pickart will answer it. This information is for the use of medical researchers and persons interested in health sciences. It must be...
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GHK WITH COPD

skinbiologywebmaster ·
This information is for the use of medical researchers and persons interested in health sciences. It must be emphasized that GHK and other copper binding peptides have not been tested on human emphysema and COPD and are not approved for such...
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Daily Copper Supplements Dangerously Low

skinbiologywebmaster ·
US Department of Agriculture studies found the best biochemical anti-oxidants results in humans were with 5 to 6 mgs of supplemental copper daily. More copper will help to some extent. The copper transport molecules are only about 50% loaded with...
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Copper Peptides Protect against UV Radiation

Jessica ·
Sun HealthIf you're like me, you love the healthy glow of sun as it tans your skin. But perhaps you ask, is tanning really safe? We hear so much these days about sunlight and cancer -- yet, why is it that we feel so happy in the sun? How can something...
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Copper Misconceptions

Jessica ·
Quite often, modern scientists toil for decades only to discover something that our ancestors knew all along from observation and keen intuition. Even after the essential discovery is made, it may take years before the official health guidelines catch up with the scientific research. It is because of this that copper, an absolutely essential element for human health, has only recently started to attract the attention of nutrition gurus. Still today, not many people know that they are at risk...
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Copper vs. GHK-Cu

Jessica ·
If copper has so many beneficial actions on its own, why do we need GHK? Copper is a very active element and as such it has to be handled carefully. Think about fire. When it burns on a stove top or in the fireplace, it brings warmth and life. But this same fire burning freely in a house brings destruction. Now think of electricity. When it is safely contained within electrical wires, it can work for us, lighting our houses and powering our appliances. But this same electricity in a form of...
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What are Copper Peptides?

skinbiologywebmaster ·
Copper peptides are the combination of small amino acid chains with copper 2+ (blue copper). Dr. Pickart's entire career focused on the question of why blood from young persons (20-25) supported cells and tissues better blood from older persons...
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GHK induces protective antioxidant protein from Gene SPRR2C

skinbiologywebmaster ·
Ultraviolet radiation increases skin damage by generating Reactive Oxygen Species (ROS) and Reactive Carbonyl Species (RCS). The Broad Institute Gene Pattern found GHK to increase the activity of the SRRR2C human gene 8.2-fold. It produces a small,...
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GHK induces genes that activate the protective Ubiquitin/Proteasome system

skinbiologywebmaster ·
The Ubiquitin/Proteasome system removes damaged proteins from cells. If these damaged proteins are not adequately removed, the cell cannot function properly. This system is also critical for the repair of damaged DNA after ultraviolet radiation...
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GHK-Cu In relation to Wound Healing

skinbiologywebmaster ·
Dr. Pickart had me post this for your reading enjoyment. In 1984, I observed that GHK-Cu possesses a mild antioxidant activity similar to the enzyme superoxide dismutase, which manifests itself as a calming of red and irritated skin. Steve Aust’s lab at Utah State University discovered that GHK-Cu blocks the damage-induced release of oxidizing iron molecules from ferritin. Further discoveries followed. Vinci et al. at the University of Catalina in Italy reported that GHK-Cu blocks tissue...
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Application of peptide gly-his-lys for analgesic effect in pain caused by thermal stimulation

skinbiologywebmaster ·
IPC classes: fficial%26channel%3Dsb&rurl=translate.google.com&sl=ru&u=http://www.freepatent.ru/MPK/A/A61/A61K/A61K38/A61K3806&usg=ALkJrhhaheibcAMPOYKoAGZ_zF2YheKOUg" target="_blank">A61K38/06 .. tripeptides fficial%26channel%3Dsb&rurl=translate.google.com&sl=ru&u=http://www.freepatent.ru/MPK/A/A61/A61P/A61P3/A61P302&usg=ALkJrhhbQxB8aTcSnHtl_Y5UdwEC8ggtFQ" target="_blank">A61P3/02 . nutrients such as vitamins, minerals, Author (s): Dolgintsev Maxim E.
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GHK Anti-Pain (Analgesic)

skinbiologywebmaster ·
GHK- Anti-Pain (Analgesic) and Anti-Anxiety (Anxiolytic) Actions 1. Opiate peptides help with wound healing and pain control. This appears to be mediated through the opioid mu1 recpetors. 2. GHK possesses both wound healing and anti-pain activities. Based on Broad Institute data, GHK increases expression of the opioid mu1 gene OPRM1 by 13.9 fold. It also increases gene expression of the cannabinoid pain-reducing gene CNR1 by 2.7 fold (average of +3.1 and +2.3). 3. This anti-pain and wound...
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GHK and Anti-Anxiety

skinbiologywebmaster ·
Anti-Anxiety (Anxiolytic) Use of peptide gly-his-lys for anxiolytic effect. RU patent 2480232.   SUBSTANCE: invention refers to medicine, namely physiology, pathophysiology and pharmacology, and may be used for an anxiolytic (antianxiety) effect....
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GHK-Cu and Inflammatory Bowel Disease Study

Skin Biology ·
Intestinal and Stomach Healing GHK-Cu has potent effects on the healing of stomach ulcers and intestinal inflammations. One small human study found a very positive effect of GHK-Cu on the healing of intestinal lesions in persons with refractory...
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One of the Most Important Papers Published!

Skin Biology ·
This information is for the use of medical researchers and persons interested in health sciences. It must be emphasized that GHK and other copper binding peptides have not been tested on human cancers and are not approved for such uses.    ...
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4 Basic Changes of Aging: How GHK Combats Each of Them

Skin Biology ·
What Happens to Our Skin as We Get Older? There are 4 basic biochemical changes our skin goes through during the aging process:   Change 1:  The rate of the skin cell replacement decreases, producing a thinner, more fragile skin. Skin is...
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GHK and Bone Healing in Humans!

Skin Biology ·
The people at the University of Kursk in Russia have found an improved method in the use of GHK. They used Gly-His-Lys (0.5 μg/kg), dalargin (1.2 μg/kg) (an opioid-like synthetic drug) and and biological peptide thymogen (0.5 μg/kg) (dipeptide,L-glutamyl-L-tryptophan) to heal bones. The total peptide dosage is about 2 micrograms per KG or about 140 micrograms in a human. It has been established, that in case of experimental rat bone fractures the intraperitoneally injections of peptides in...
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NEW Navigation Bar - Highlights 17 Effects of GHK

Skin Biology ·
Dear Researchers & Visitors: You'll be happy to know that we have a NEW navigation bar that will facilitate your search for copper peptide studies and effects. This navigation box will be able to be found on the right hand side of our science sites . We are working on slowly dispersing this box so that it is easy to locate on whatever page you are navigating. Why is this so important? In one single area, you'll be able to see an overview of numerous important skin and...
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NEW BOOK! Dr. Pickart's 3rd Edition of Reverse Skin Aging

Skin Biology ·
Looking for the latest news and updates on the science behind Dr. Loren Pickart's discovery of copper peptides?   We are proud to announce the availability of his 3rd Edition of the book aptly titled Reverse Skin Aging - What Copper Peptides Can...
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Over 30% of Human Genes Affected by GHK-Cu? YES

Skin Biology ·
The Broad Institute in Boston (managed by Harvard and MIT) analyzes the effect of molecules on human genes to predict the most effective method for the treatment of diseases. Their Connectivity Map is a large database that contains more than...
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A Must-Read! NEW 3rd Edition of Reverse Skin Aging

Skin Biology ·
Looking for the latest news and updates on the science behind Dr. Loren Pickart's discovery of copper peptides?   We are proud to announce the availability of his  3rd Edition of the book  aptly titled  Reverse Skin Aging - What...
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GHK and DNA: Resetting the Human Genome to Health

skinbiologywebmaster ·
Abstract: During human aging there is an increase in the activity of inflammatory, cancer promoting, and tissue destructive genes plus a decrease in the activity of regenerative and reparative genes. The human blood tripeptide GHK possesses many positive effects but declines with age. It improves wound healing and tissue regeneration (skin, hair follicles, stomach and intestinal linings, and boney tissue), increases collagen and glycosaminoglycans, stimulates synthesis of decorin, increases...
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Approved for Publication! NEW Review Article on GHK & Skin Regeneration

Skin Biology ·
Approved for Publication! NEW Review Article on GHK & Skin Regeneration Dr. Loren Pickart's latest review article has been approved for publication and was released in the April 2015 edition of BioMed Research International [this publication focuses on research articles in multiple areas of life sciences and was formerly known as Journal of Biomedicine and Biotechnology ]. Here is a brief excerpt of what you can expect to learn when you download your free copy : GHK Peptide as a Natural...
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NEW ARTICLE: Power of GHK-Cu on Modifying Gene Expression

Skin Biology ·
GHK-Cu May Prevent Oxidative Stress in Skin by Regulating Copper and Modifying Expression of Numerous Antioxidant Genes Loren Pickart , Jessica Michelle Vasquez-Soltero and Anna Margolina Accepted: 21 July 2015 | Published: 28 July 2015 ABSTRACT: The copper binding tripeptide GHK (glycyl-l-histidyl-l-lysine) is a naturally occurring plasma peptide that significantly declines during human aging. It has been established that GHK:Copper(2+) improves wound healing and tissue regeneration and...
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GHK Anti-Pain and Anti-Anxiety Actions: What Does It Mean?

Skin Biology ·
GHK- Anti-Pain (Analgesic) and Anti-Anxiety (Anxiolytic) Actions: Study Reveals Interesting Effects   Application of peptide gly-his-lys for analgesic [anti-pain] effect in pain caused by thermal irritation. RU patent 2421235.   EFFECT:  Invention allows applying known peptide Gly-His-Lys with manifested analgesic effect for a new purpose.   The invention relates to medicine, namely to the physiology and pathophysiology, and can be used for an analgesic effect in the pain...
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Copper & Alzheimer’s Disease: Clearing Up Confusion

Skin Biology ·
Copper, Your Cerebrum, and The Truth About Brain Function & Mental Health The first evidence for the essential role copper plays in the human body was obtained in 1928. When rats were kept on an iron-free milk diet, they developed severe anemia. Today, we know that copper is absolutely essential for life. No other metal can replace it. Fortunately, severe deficiency of this metal is rare and is observed mostly in experiments. However, even marginal copper deficiency can be dangerous and...
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GHK Proved Similar to NSAIDs - How?

Skin Biology ·
NSAIDs and GHK: Unexpected Similarities! G HK and GHK-Cu may function as the circulating human non-steroidal anti- inflammatories (NSAIDs). In human plasma there is about 200 nanograms per milliliters of GHK and GHK-Cu at age 20. This declines to...
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Youthful Skin Begins with Hair Follicles

Skin Biology ·
Youthful Skin Begins with Hair Follicles   Beautiful hair and skin are interconnected in ways many of us may not realize. For the key to remodeling and rejuvenating skin begins with our hair follicles. When the body signals skin to remodel and...
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FIND THE INFORMATION YOU NEED

Skin Biology ·
Searching for Information on the Science of Copper Peptides? It's Time to Pick Up Your Copy Find the information you need in Dr. Pickart's comprehensive publication Reverse Skin Aging - What Copper Peptides Can Do For You . No other book is as heavily referenced with dermatological studies and independent research that present an impressive body of scientific evidence on the age-reversal power of copper peptides. Challenge the belief that aging is inevitable. Today, scientific studies from...
 
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