Application of copper peptide in cosmetics
Copper Peptide(GHK-Cu), (CopperTripeptide-1), also known as copper Shengpeptide, is a complex composed of tripeptide (GHK) and copper ions. In recent years, the blue copper peptide has become one of the most popular high-end cosmetic raw materials on the market because of its small molecule, easy absorption, high activity and no stimulation. As a rising star in the functional raw material, blue copper peptide unique blue-purple crystal appearance, which makes it particularly unusual. GHK-Cu from Xi’an Lyphar Biotech makes your cosmetics more effective.
Copper peptide has many physiological functions to promote the production of blood vessels and nerves; regulate the synthesis of collagen, elastin and glycosaminoglycans; reduce inflammation, and promote the generation of oxidoreductase and antioxidants. Clinical studies have proved that copper peptide has a powerful wrinkle removal effect, can act on the epidermis and dermis, stimulate skin thickness to increase skin synthesis, significantly smooth skin, and increase skin elasticity.
After the comparison experiment before and after the use of copper peptide, one can obviously see its obvious effect in removing the redness of sensitive skin and removing wrinkles around the eyes. Currently, the three most widely used fields of copper peptide are wrinkle removal, repair and anti-aging.The copper peptide has many physiological functions to promote the production of blood vessels and nerves; regulate the synthesis of collagen, elastin and glycosaminoglycans; reduce inflammation, and promote the generation of oxidoreductase and antioxidants.
Skin care products containing copper peptides have the following effects:
- Tighten the skin and improve skin elasticity;
- Improve the skin transmittance;
- Improve the density and tightness of the skin;
- Reduce light damage and color spots;
- Reduce fine lines and deep wrinkles;
- Greatly increased the proliferation of keratinocytes;
Preparation and mechanism of action:
GHK-Cu is able to cross the cuticle and is quantitatively sufficient to activate regeneration. They are increasing permeability increases with pH. Studies have shown that GHK and GHK-Cu can cross the cuticle, but it is essential to ensure enough copper peptide absorption. Researchers treated biotinylated copper peptide wounds bound to the collagen matrix, and their study found that GHK-Cu improved wound contraction and increased cell proliferation and the expression of antioxidant enzymes. Recent studies have examined the stable conditions of GHK-Cu: easy hydrolysis under oxidative conditions and storage for two weeks at 60℃ in water or in a buffer at pH 4.5-7.4.
Usage and dosage:
Skin repair peptide-1 uses copper peptide powder as a product and can be added in the final stage of cosmetics production. The preparation temperature should be less than 40℃.
The recommended concentration: is 500ppm-2,000ppm.
Determine the quality of the copper peptide:
In fact, ineffective chelation, the copper peptide has a blue crystal shape, rather than a powder. Moreover, such crystal-shaped peptides have more advantages than powder:
Higher purity, better quality, more stable nature, higher bioavailability, and ease to store and operation.
- Avoid mixing with substances with strong reducing, anionic and acidic, such as VC, PGA, nicotinamide, Kao, EDTA disodium, some fructose, octyl hydroxamic acid, etc. A change in the copper coordinating compound also changes its color in the aqueous solution.
- Copper peptides avoid below PH3 with an optimal range of 5–7.