GHK- Anti-Pain (Analgesic) and Anti-Anxiety (Anxiolytic) Actions: Study Reveals Interesting Effects
Application of peptide gly-his-lys for analgesic [anti-pain] effect in pain caused by thermal irritation. RU patent 2421235.
EFFECT: Invention allows applying known peptide Gly-His-Lys with manifested analgesic effect for a new purpose.
The invention relates to medicine, namely to the physiology and pathophysiology, and can be used for an analgesic effect in the pain caused by thermal stimulation.
In the literature, many authors described the properties of the peptide Gly-His-Lys. Known for its modulating effect in the regulation of cell growth and differentiation (Kato K., Kasai S., Onodera K. et al. Effect of hepatocyte growth factor on the proliferation of transplanted hepatocytes in the spleen. / / Transplant. Proc. - 1997. - Vol.29, № 4. - P.2029-2031; Sporn MB, Roberts AB Transforming growth factor-in: recent progress and new challenges. / / J. Cell Biol. - 1992. - Vol.119, № 5. - P.1017-1021). Several studies have confirmed the effect of the peptide as a stimulator of wound healing, as is known for its stimulating effect on collagen synthesis by fibroblasts (Maquart FX, Bellon G., Chaqour V. et al. In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L- histidyl-L-lysine-Cu2 + in rat experimental wounds. / / J. Clin. Invest. - 1993. - Vol.92, № 5. - P.2368-2376). It is shown that Gly-His-Lys promotes stimulation of physiological and reparative regeneration of the liver (Smakhtin MY, sewing IA, Hemp AA Bobyntsev II method for stimulating physiological and reparative regeneration of the liver. - Patent for invention number 2214269, of 20.10.2003). Known as a stimulating effect on hair growth peptide (Trackhy RE, Fors TD, Pickart L., Uno H. The hair follicle-stimulating properties of peptide copper complexes. Results in C3H mice / / Ann. N.-Y. Acad. Sci. - 1991. - Vol.642, № 10. - P.468-469) and anti-inflammatory effect associated with a decrease in iron release from ferritin in the damaged tissues (Miller DM, DeSilva D., Pickart L., Aust SD Effects of glycyl- histidyl-lysyl chelated Cu (II) on ferritin dependent lipid peroxidation / / Adv. Exp. Med. Biol. - 1990. - Vol.264. - P.79-84.).
The object of the invention is the use of a new purpose peptide Gly-His-Lys, having the formula: (NH 2) Gly-His-Lys (COOH), for an analgesic effect in the pain caused by thermal stimulation...
...The results of experimental studies have shown that the use of the peptide Gly-His-Lys at doses of 0.5 and 5 mg / kg caused a pronounced analgesic effect in the pain provoked by thermal stimulation. This method is based on the use of regulatory peptides, belonging to the class of biologically active substances with a pronounced and polyfunctional modulatory effect is not tedious and does not require the use of complex equipment.
Use of peptide gly-his-lys for anxiolytic [anti-anxiety] effect. RU patent 2480232.
EFFECT: invention provides the use of peptide Gly-His-Lys by the new application, namely for anxiolytic action. The invention relates to medicine, namely to physiology, pathophysiology and pharmacology, and can be used for anxiolytic effect. In the literature a number of researchers describes the properties of the peptide Gly-His-Lys...
Dissolved in izotonicescom solution of sodium chloride peptide Gly-His-Lys impose experimental animals (rats) parenteral (injected) once in doses of 0.5 and 5 mg/kg body weight 12 minutes before the start of the study.
Specific example of the Experimental animals (rats-males Wistar) weighing 200-250 g were divided into groups of 10 animals each (table). Animals were kept at room temperature 22-24 C, light mode: 12 hours of light and 12 hours - darkness, and received a standard granulated food and water in the public domain...
When using peptide Gly-His-Lys in doses of 0.5 and 5 mcg/kg marked anxiolytic effect (table). Thus, the results of the experimental studies show that the use of peptide Gly-His-Lys in doses of 0.5 and 5 mg/kg caused a pronounced anxiolytic effect. This method is based on application of regulatory peptide belonging to class of biologically active substances with strong effect and, is not time consuming and requires the use of sophisticated machinery. Application of peptide Gly-His-Lys with formula (NH2 )Gly-His-Lys(COOH), for the anxiolytic effect.
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