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Intestinal and Stomach Healing

GHK-Cu has potent effects on the healing of stomach ulcers and intestinal inflammations. One small human study found a very positive effect of GHK-Cu on the healing of intestinal lesions in persons with refractory inflammatory bowel disease.


Effects of GHK-Cu on gastric acidity,

mucous production and the development of ulcers  

(Shay gastric ulcer model (95% ethanol) in rats). 

Dosage of GHK-Cu Stomach pH
Rats with visible gastric 
Gastric mucous production
1 milligram3.8
3 milligrams4.7
10 milligrams6.7


Likewise, GHK-Cu produced a similar blockage of rat duodenal ulcer formation (cystamine induced).

Stomach and
intestinal ulcers

GHK-Cu was tested for healing of experimental stomach ulcers and intestinal damage in rats.

GHK-Cu healed experimental stomach ulcers and intestinal inflammation and damage          

Pickart US Patent 4,767,753
US Patent 5,023,237  
US Patent 5,145,838
Cytoprotective actions against oxygen free radicalsa
GHK-Cu markedly inhibited intestinal mucosal tissue from lipid peroxidation by oxygen-derived free radicals         a
Cytoprotective effect of copper(II) complexes against ethanol-induced damage to rat gastric mucosa, J Inorg Biochem. 
Human Study:
bowel disease

16 patients with refractory inflammatory bowel disease were treated with rectally administered solutions of GHK-Cu.

After the 12 weeks treatment, there was a 60% reduction in severity bas measured by endoscopy, histopathology, and symptoms                                             

An open study of PC1020 (GHK-Cu) rectal solution in treatment of distal inflammatory bowel disease.  Levine, Patt, Koren  (University of Washington) World Congress of Dermatology. 

Dr. Loren Pickart who has a BA in Chemistry and Mathematics from the University of Minnesota and a PhD in Biochemistry from the University of California, San Francisco is dedicated to the research and further discussion of biochemistry, science, and health in all its applications.

Last edited by Skin Biology
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