Skip to main content


Resetting Skin Genome Back to Health Naturally with GHK

Textbook of Aging Skin (Reference Book Abstract)

The copper-binding tripeptide GHK (glycyl-l-histidyl-l-lysine) is a naturally occurring plasma peptide widely used in skin care products. It is especially popular in antiaging cosmetic formulations due to its various and well-established positive biological effects on aging skin. It has been established that GHK-Cu improves wound healing and tissue regeneration and stimulates collagen and decorin production.

GHK-Cu also supports angiogenesis and nerve outgrowth, improves the biological condition of aging skin and hair and possesses DNA repair, antioxidant, and anti-inflammatory effects. In addition, it increases cellular stemness and secretion of trophic factors by mesenchymal stem cells.

GHK’s antioxidant actions have been demonstrated in vitro and in animal studies. They include blocking the formation of reactive oxygen and carbonyl species, detoxifying toxic products of lipid peroxidation such as acrolein, protecting keratinocytes from lethal UVB radiation, and blocking hepatic damage by dichloromethane radicals.

In recent studies, GHK has also been found to switch cellular gene expression from a diseased state to a healthier state for certain cancers and for chronic obstructive pulmonary disease (COPD).

The human gene expression actions provide a unique view of the complex and intricate gene actions underlying visible changes in human skin.

For more information, see:

Dr. Loren Pickart who has a BA in Chemistry and Mathematics from the University of Minnesota and a PhD in Biochemistry from the University of California, San Francisco is dedicated to the research and further discussion of biochemistry, science, and health in all its applications.


Images (1)
  • TextbookofAging_GHKSm
Last edited by Skin Biology
Original Post

Add Reply

Link copied to your clipboard.